NU-DIPHOSPHINES: Stoichiometric and Catalytic Synthesis and Applications in Asymmetric Catalysis
The importance of phosphorus(III) based ligands in academic research and industrial scale synthesis cannot be overemphasized and a number of important processes rely on such ligands to achieve commercially viable activities and selectivities. As the synthesis of chiral diphosphines is often an elaborate non-trivial multi-step process we have been developing entirely new approaches that are operationally straightforward, inexpensive and highly modular. This lecture will discuss our use of stoichiometric zirconium-mediated reductive coupling, thermal Diels-Alder reactions and rhodium-catalysed [2+2+2] cycloaddition towards the synthesis of tropos and atropos biaryl and biaryl-like diphosphines, their coordination chemistry and applications in asymmetric catalysis
The importance of phosphorus(III) based ligands in academic research and industrial scale synthesis cannot be overemphasized and a number of important processes rely on such ligands to achieve commercially viable activities and selectivities. As the synthesis of chiral diphosphines is often an elaborate non-trivial multi-step process we have been developing entirely new approaches that are operationally straightforward, inexpensive and highly modular. This lecture will discuss our use of stoichiometric zirconium-mediated reductive coupling, thermal Diels-Alder reactions and rhodium-catalysed [2+2+2] cycloaddition towards the synthesis of tropos and atropos biaryl and biaryl-like diphosphines, their coordination chemistry and applications in asymmetric catalysis
